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Physical Activity, Body Size, Intentional Weight Loss and Breast Cancer Risk: Fellowship

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Annual rept. 1 Oct 1997-30 Sep 1998

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This postdoctoral training award supports studies to describe elements of energy balance and breast cancer incidence. The modifying effect of early-life body size and weight change on associations between early-life physical activity and breast cancer risk was evaluated using extant data from a case-control study of breast cancer. Cases n6888 were identified through four state-wide cancer registries controls n9529 were randomly selected from population lists. Results suggest that, in premenopausal women, the relation between early-life physical activity and breast cancer risk is similar across all strata of early-life body size and weight change. In postmenopausal women, results suggest that risk reduction associated with physical activity may be greatest in women who were heaviest at age 18, and in women who maintained a stable weight between age 18 and 5 years prior to diagnosis, independent of initial weight. Preliminary data were obtained on intentional weight loss and weight reduction methods from the successful addition of relevant questions to an on-going case-control study of breast cancer. Responses to these questions suggest small, but potentially important, differences between cases and controls regarding patterns of intentional weight loss, choice of weight reduction method, and amount of weight lost.

Subject Categories:

  • Medicine and Medical Research
  • Food, Food Service and Nutrition
  • Stress Physiology

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