Accession Number:

ADB247801

Title:

Lewis Y Antigen as a Target for Breast Cancer Therapy

Descriptive Note:

Final rept. 1 Sep 94-31 Aug 98

Corporate Author:

PENNSYLVANIA UNIV PHILADELPHIA WISTAR INST

Personal Author(s):

• Kieber-Emmons, Thomas

Report Date:

1998-09-01

Pagination or Media Count:

121.0

Abstract:

The Lewis Y antigen is a breast cancer associated carbohydrate antigen. The basis of the program was to establish and utilize structural information for Lewis Y-antibody interactions to develop novel immunotherapeutics for breast cancer treatment. It is postulated that the Lewis Y determinant on human breast adenocarcinoma cells is of key Importance since it mediates internalization and lethal function of Lewis Y specific MAb. During the course of the funding period we have 1 established the molecular recognition properties of several anti-Lewis antibodies for Lewis Y, 2 established that peptide mimotopes of adenocarcinoma associated carbohydrate forms that include Lewis Y may function as a breast cancer vaccine, 3 established the molecular basis for such mimicry, and 4 have constructed a humanized single chain Fv form of a potent anti-Lewis Y antibody which is being further developed as a bispecific antibody.

Descriptors:

• *DIAGNOSIS(MEDICINE)
• *ANTIBODIES
• *ANTIGENS
• *BREAST CANCER
• FUNCTIONS
• HUMANS
• STRUCTURAL PROPERTIES
• PEPTIDES
• THERAPY
• LETHALITY
• CELLS(BIOLOGY)
• CARBOHYDRATES
• MOLECULAR PROPERTIES
• VACCINES

Subject Categories:

• Medicine and Medical Research
• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE