Hormones and Breast Cancer.
Final rept. 30 Sep 96-29 Sep 97,
UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES SCHOOL OF MEDICINE
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This grant consisted of 4 separate projects Projects 1 and 4 aimed at assessing the association between lifestyle factors exogenous hormone use and breast cancer. The other two projects aimed at elucidating the role of estrogen metabolism in breast cancer development Project 2 and the association between female hormones and mammographic densities, a possible intermediate endpoint for breast cancer Project 3. Oral contraceptive use was not found to explain the increase in breast cancer risk that Asian migrants experience the first decade after they migrate to the US Project 1. However, oral contraceptive use at a young age was associated with early onset breast cancer in young women aged 35 or younger, while recent use appeared to be a more important risk factor in middle aged women aged 36-4 Project 4. Results from Project 2 suggest that the ratio of the two urinary estrogen metabolites 2-hydroxyestrone and 1 6a-hydroxyestrone does not differ between postmenopausal breast cases and controls or between premenopausal women at high and normal risk of breast cancer. Project 3 suggested that reducing serum-levels of hormones reduced the amount of mammographic densities. The results from the last project may prove useful for cancer prevention studies.
- Medicine and Medical Research