Accession Number:

ADB234439

Title:

Biological Markers of Environmental Carcinogens in Breast Cancer

Descriptive Note:

Annual rept. 1 Oct 1996-30 Sep 1997

Corporate Author:

COLUMBIA UNIV NEW YORK

Personal Author(s):

Report Date:

1997-10-01

Pagination or Media Count:

29.0

Abstract:

This ongoing case-control study is being conducted at the Columbia Presbyterian Medical Center CPMC and is investigating whether exposures to the environmental and dietary contaminants polycyclic aromatic hydrocarbons PAR and heterocyclic amines HA are associated with risk of breast cancer. The study is designed to enroll 100 cases and 100 benign breast disease BBD controls from whom blood, biopsy tissue and questionnaire data are being collected, as well as 100 healthy controls from whom blood and questionnaire data are being collected. The study is utilizing biomarkers PAN-, HA-, and smoking related-DNA adducts as measures of exposure and a biomarker of pre-clinical effects p53 muations. During year three, patient recruitment continued and an increased focus was placed on the laboratory aspects of the study. Progress in patient recruitment has been excellent and is running ahead of schedule with 384 patients currently enrolled. Thus far, a total of 2,400 analyses have been performed on blood samples and 351 analyses have been performed on tissue samples . Descriptive statistical analyses of the data have been carried out. Additionally, samples have been used for several pilot studies and the descriptive analyses for these biomarkers are presented as well.

Subject Categories:

  • Biology
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE