Vascular Functional Imaging and Physiological Environment of Hyperplasia, Non-Metastatic and Metastatic Breast Cancer
Annual rept. 1 Oct 1996-30 Sep 1997
JOHNS HOPKINS UNIV BALTIMORE MD
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Our research proposal consists of the following three closely related aims directed towards understanding the role of vascular, physiological and metabolic properties in the metastatic dissemination of breast cancer. Aim 1 To investigate the relationship between metastatic phenotype and the development of vascularization and evaluate the functionality of the developing vascularization in terms of vascular volume, vascular permeability and relative perfusion. Aim 2 To investigate the effect of increasing a tumor vascularization and b tumor vascularization and permeability on the formation of metastases. Aim 3 To determine the relationship between metastatic phenotype and intra- and extracellular pH and lactate production.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research