Accession Number:

ADB233883

Title:

Vascular Functional Imaging and Physiological Environment of Hyperplasia, Non-Metastatic and Metastatic Breast Cancer

Descriptive Note:

Annual rept. 1 Oct 1996-30 Sep 1997

Corporate Author:

JOHNS HOPKINS UNIV BALTIMORE MD

Personal Author(s):

Report Date:

1997-10-01

Pagination or Media Count:

29.0

Abstract:

Our research proposal consists of the following three closely related aims directed towards understanding the role of vascular, physiological and metabolic properties in the metastatic dissemination of breast cancer. Aim 1 To investigate the relationship between metastatic phenotype and the development of vascularization and evaluate the functionality of the developing vascularization in terms of vascular volume, vascular permeability and relative perfusion. Aim 2 To investigate the effect of increasing a tumor vascularization and b tumor vascularization and permeability on the formation of metastases. Aim 3 To determine the relationship between metastatic phenotype and intra- and extracellular pH and lactate production.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE