Accession Number:

ADB233503

Title:

Megakaryocytopoiesis in Stem Cell Transplantation

Descriptive Note:

Annual rept. 16 Sep 96-15 Sep 97

Corporate Author:

NORTHWESTERN UNIV EVANSTON IL

Personal Author(s):

Report Date:

1997-10-01

Pagination or Media Count:

26.0

Abstract:

The overall objective of this research proposal is to investigate several laboratory protocols to improve megakaryocyte production for future clinical use of an autologous megakaryocyte-rich product. Conditioned medium from bone marrow stromal cultures enhances the thrombopoietin stimulated megakaryocyte production by at least 3-fold by a still unknown mechanism. We were able to rule out any role of stromal concentrations of thrombopoietin, interleukins 3 and 6, stem cell factor and heparan sulfates on this enhancing effect.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE