Megakaryocytopoiesis in Stem Cell Transplantation
Annual rept. 16 Sep 96-15 Sep 97
NORTHWESTERN UNIV EVANSTON IL
Pagination or Media Count:
The overall objective of this research proposal is to investigate several laboratory protocols to improve megakaryocyte production for future clinical use of an autologous megakaryocyte-rich product. Conditioned medium from bone marrow stromal cultures enhances the thrombopoietin stimulated megakaryocyte production by at least 3-fold by a still unknown mechanism. We were able to rule out any role of stromal concentrations of thrombopoietin, interleukins 3 and 6, stem cell factor and heparan sulfates on this enhancing effect.
- Anatomy and Physiology
- Medicine and Medical Research