Accession Number:

ADB233224

Title:

Extrudable Gel-Forming Bioabsorbable Hemostatic Tissue Adhesives for Traumatic and Burn Wounds

Descriptive Note:

Final rept. 28 Jun 96-27 Jun 97

Corporate Author:

POLY-MED INC ANDERSON SC

Personal Author(s):

Report Date:

1997-07-01

Pagination or Media Count:

29.0

Abstract:

The three segments of the planned studies, adhesive skin wound augmentation ASWA, burn wound healing BWH, and hemostatic sealants HS were successfully completed. Results on ASWA led to the identification of an absorbable extrudable gel-former which can be used in conjunction with skin stapling to reduce the number of staples needed to approximate wound edges by about half, while increasing significantly the percent regain in would strength and controlling scar formation. Relative to BWH, a representative gel-former was found to assist in accelerating the healing process while reducing scar formation as indicated by the extent of epithelization and width of dermal fibroplastia. A novel gel-forming system was demonstrated as an effective hemostatic sealing agent. Plans are in place to explore further these three segments to verify these findings following modified protocol and larger number of animals. This is to be followed by development and scale-up studies of at least two systems.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE