Fluorescence Lifetime Imaging for Breast Cancer Detection
Annual rept. 1 Jul 1996-30 Jun 1997
PURDUE RESEARCH FOUNDATION LAFAYETTE IN
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New screening tools are needed for women for whom x ray mammography is not suitable. We present a new and novel modality called fluorescence lifetime imaging as a potential tool for breast cancer detection and diagnosis. In this technique, the contrast for the diseased tissue is provided by a change in lifetime of fluorescent contrast agents such as porphyrins or some of the newly synthesized lifetime sensitive dyes. Our study involves experimental and computational approaches to explore the technical feasibility of this technique. Experimental studies are planned which include frequency domain measurements of the fluorescent light in a multiple detector - multiple source arrangement. Measurements will be performed for analyte sensitive dyes in heterogeneous tissue phantoms. These measurements will be used as inputs to a developed inverse imaging algorithm to obtain an image of lifetime. Since probe or dye lifetimes are sensitive to biochemical environment, diagnostic information is also obtained in addition to detection of disease. Preliminary computational and experimental results are promising and suggest a new imaging modality with specificity for breast disease.
- Medicine and Medical Research