Episome-Based Gene Therapy Strategy for Treatment of Human Breast Cancer
Annual rept. 22 Dec 95-21 Dec 96
CASE WESTERN RESERVE UNIV CLEVELAND OH
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E HAVE FOCUSED OUR EFFORTS ON INVESTIGATING THE EFFECTIVENESS OF ANTISENSE TO TYPE I insulin-like growth factor receptor IGF-IR in reducing tumorigenicity in highly metastatic human breast cancer cells, MDA-MB-435S and murine breast cancer cells, EMT6 in vitro and in vivo. A new construct for antisense IGF-IR has been prepared and transfections were carried out in these cell lines. Clones expressing high levels of antisense IGF-IR and reduced IGF-IR RNA were selected for analysis.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research