Studies on Platelet-Derived Growth Factor Beta-Receptor and Hepatocyte Growth Factor Receptor c-met in Paracrine Interactions in Human Breast Cancer
Final rept. 1 Sep 94-31 Aug 96
QUEEN'S UNIV KINGSTON (ONTARIO)
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The overall aim of our project is to identify paracrine and autocrine mechanisms that regulate stromal-tumor cell interactions in breast cancer. We have shown that platelet-derived growth factor PDGF Beta-receptors, which are high affinity receptors for PDGF-BB, are upregulated in vascular endothelial cells and smooth muscle actin-expressing cells most likely myofibroblasts at the peri-epithelial stroma in DCIS of human breast tumors. Our results suggest that breast carcinoma cells, which secrete PDGF-BB, stimulate vascularization by endothelial cells and recruitment of myofibroblasts in the peri-epithelial stromal regions of early stage breast cancer.
- Anatomy and Physiology
- Medicine and Medical Research