Accession Number:

ADB224557

Title:

Studies on Platelet-Derived Growth Factor Beta-Receptor and Hepatocyte Growth Factor Receptor c-met in Paracrine Interactions in Human Breast Cancer

Descriptive Note:

Final rept. 1 Sep 94-31 Aug 96

Corporate Author:

QUEEN'S UNIV KINGSTON (ONTARIO)

Personal Author(s):

Report Date:

1996-09-01

Pagination or Media Count:

62.0

Abstract:

The overall aim of our project is to identify paracrine and autocrine mechanisms that regulate stromal-tumor cell interactions in breast cancer. We have shown that platelet-derived growth factor PDGF Beta-receptors, which are high affinity receptors for PDGF-BB, are upregulated in vascular endothelial cells and smooth muscle actin-expressing cells most likely myofibroblasts at the peri-epithelial stroma in DCIS of human breast tumors. Our results suggest that breast carcinoma cells, which secrete PDGF-BB, stimulate vascularization by endothelial cells and recruitment of myofibroblasts in the peri-epithelial stromal regions of early stage breast cancer.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE