Accession Number:

ADB223532

Title:

Novel Membrane System to Automatically Deglycerolize Thawed Frozen Human Blood. Phase II

Descriptive Note:

Annual rept. 15 Mar 95-14 Mar 96

Corporate Author:

ADVANCED HAEMO TECHNOLOGIES THE WOODLANDS TX

Report Date:

1996-04-01

Pagination or Media Count:

75.0

Abstract:

Improved methods for frozen storage of glycerolized red blood cells RBCs are needed both to meet military and civilian needs in periods of high demand. Existing degycerolization systems are labor intensive and considered open systems resulting in a maximum storage of 24 hours following washing. The washing of blood cells with flat sheet membrane filters has been proven effective by the Advanced Haemotechnologies. AHTS thawed blood processing system development in year one of the Phase II proposal has focused on optimizing the disposable operation and configuration as well as developing hardware. Suggested key operational parameters include the total volume concentration of blood in the filter and shear induced hemolysis of the blood during washing. Advances in each of the areas were made for washing fresh and frozen thawed red blood cells. Successful completion of the Phase H development will lead to a closed, sterile washing system for thawed blood and should allow for extended storage thawed RBC products.

Subject Categories:

  • Medicine and Medical Research
  • Medical Facilities, Equipment and Supplies

Distribution Statement:

APPROVED FOR PUBLIC RELEASE