Cytokines, Neovascularization and Breast Cancer
Annual Rept. 1 Oct 1995-30 Sep 1996
CONNECTICUT UNIV HEALTH CENTER FARMINGTON
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Angiogenesis is critical for breast cancer growth and metastasis. This process is controlled by chemical signals known as angiogenic factors. To date little is known about the source or regulation of angiogenic factor expression. We hypothesize that in human breast cancer, the breast cancer cells are the source of angiogenic factors. Further, this angiogenic factor expression is directly under the control of cytokines and other factors such as fibrin that are normally found in healing wounds. In order to study this question, we are examining the expression and regulation of angiogenic factor expression, specifically IL-8. in human breast tissue, an in vitro model of human breast cancer cells, and in an in vitro model in immunodeficient mice. We have demonstrated that IL-8 is present in breast cancer specimens by immunohistologic analysis, and in breast cancer homogenates. We have also demonstrated that IL-1 is a potent inducer of IL-8 expression by estrogen independent breast cancer cells. Our results from Years 01 and 02 confirm our original hypothesis, and have set the ground work for the mouse model studies of Years 03 and 04. In the future, treatment of breast cancer may include specific agents designed to interfere with angiogenesis.
- Anatomy and Physiology
- Medicine and Medical Research