Accession Number:

ADB222551

Title:

Biochemistry and Chemotherapy of Leishmaniasis and Malaria

Descriptive Note:

Annual rept. 2 Nov 94-1 Nov 95

Corporate Author:

MASSACHUSETTS UNIV AMHERST

Personal Author(s):

Report Date:

1995-12-01

Pagination or Media Count:

62.0

Abstract:

Leishmaniasis, a disease caused by protozoan parasites of the Leishmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease are either ineffective or toxic. Malaria is considered to be the most important infectious disease of humans on a world-wide scale. The purpose of this work is to aid in the development of an effective, non-toxic treatment for leishmaniasis and malaria. The objective of this research was to 1 Determine the action of the antimalarial 8-aminoquinolines on Leishmania sp., 2 To identify and characterize unique DNA synthetic enzymes for the purpose of chemotherapeutic exploitation and 3 To test potential compounds sent by WRAIR and others for anti- parasitic activity.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Microbiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE