Biochemistry and Chemotherapy of Leishmaniasis and Malaria
Annual rept. 2 Nov 94-1 Nov 95
MASSACHUSETTS UNIV AMHERST
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Leishmaniasis, a disease caused by protozoan parasites of the Leishmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease are either ineffective or toxic. Malaria is considered to be the most important infectious disease of humans on a world-wide scale. The purpose of this work is to aid in the development of an effective, non-toxic treatment for leishmaniasis and malaria. The objective of this research was to 1 Determine the action of the antimalarial 8-aminoquinolines on Leishmania sp., 2 To identify and characterize unique DNA synthetic enzymes for the purpose of chemotherapeutic exploitation and 3 To test potential compounds sent by WRAIR and others for anti- parasitic activity.
- Medicine and Medical Research