Estrogen Receptor Mutants/Variants in Human Breast Cancer.
Annual rept. 15 Nov 95-14 Nov 96,
MANITOBA UNIV WINNIPEG
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We have identified in a range of human breast cancer biopsy samples, several known and unknown estrogen receptor ER variant mRNAs as well as some ER mRNAs containing inserted nucleotide sequences. The variant ER mRNAs are likely generated by alternative splicing mechanisms, while the inserted ER mRNAs are likely to be generated from a mutated ER allele in the tumor cells. All types of variant ER mRNAs so far identified, could be detected in normal human mammary tissue. The expression of some of these variant ER mRNAs was significantly higher in breast tumors than in normal breast tissue. Moreover, the pattern of ER variant mRNA expression changes in breast tumors and breast cancer cells with characteristics of poor prognosis and lack of sensitivity to endocrine therapies.
- Anatomy and Physiology
- Medicine and Medical Research