Accession Number:

ADB222349

Title:

Mechanisms of Integrin-Mediated Growth Control in Normal, Transformed, and Neoplastic Breast Cells

Descriptive Note:

Annual rept. 30 Sep 95-29 Sep 96

Corporate Author:

SEATTLE BIOMEDICAL RESEARCH INST WA

Personal Author(s):

Report Date:

1996-10-01

Pagination or Media Count:

23.0

Abstract:

The interaction between a normal cell and its substratum, a phenomenon known as anchorage dependence, is an important determinant of the GIS transition. The cell surface receptors that mediate cell-substrate adhesion are known as integrins. Integrins are transmembrane glycoproteins. It is possible that extracellular matrix proteins regulate normal cell growth by transmitting signals to the interior via specific integrin receptors. In transformed cells such signaling pathways might be absent or dysfunctional thereby conferring unresponsiveness to normal growth constraints. The present studies are focused to understand how integrin receptors, in particular alpha 5 Beta 1, participate in the regulation of cell division in normal breast cells and to determine how breast cancer cells escape these regulatory pathways. Our initial results indicate that soluble GRGDS peptides can alter cell cycle kinase activity in both normal breast cells and in some carcinoma cell lines.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE