Tumor Suppressor Genes in Early Breast Cancer and Its Progression.
Annual rept. 1 Sep 1995-31 Aug 1996
WASHINGTON UNIV ST LOUIS MO SCHOOL OF MEDICINE
Pagination or Media Count:
An increasing percentage of breast cancer is being detected at a pre-invasive stage ductal carcinoma in situ DCIS. DCIS is a form of breast cancer in which malignant cells have not penetrated the basement membrane. The histopathological diagnosis encompasses a heterogeneous group of subtypes, including comedo, cribriform, solid, papillary and micropapillary, some of which may differ in biological behavior. The potential for associated micro invasion and likelihood of recurrence after breast conservation therapy are higher with the comedo subtype. As with invasive breast cancer, DCIS can also be stratified by nuclear grade high, intermediate, and low. Our studies have concentrated on the genetic changes which occur in DCIS and the transition from DCIS to invasive breast cancer. A better understanding of the oncogenesis of breast cancer at the molecular level, and the correlation of this information with clinical data, may aid in treatment choices.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research