The Role of Matrilysin, a Matrix Metalloproteinase, in Mammary Tumorigenesis.
Annual rept. 1 Sep 95-31 Aug 96,
VANDERBILT UNIV MEDICAL CENTER NASHVILLE TN
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The goal of this project is to test the hypothesis that the expression of matrilysin in mammary epithelial cells plays a causal role in the progression and metastasis of mammary carcinomas using a transgenic mouse model system. We have successfully generated transgenic mice expressing the metalloproteinase matrilysin, under the control of the mammary specific MMTV promoterenhancer. In this report we demonstrate that matrilysin accelerates the development of mammary tumors in the MMTV-neu transgenic animals. Current studies involve investigating the possibility that matrilysin is proteolytically processing members of the EGFerbB signal transduction pathway, thereby constitutively activating this pathway and accelerating mammary tumor formation.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research