Multigenerational Breast Cancer Risk Factors in African-American Women
Annual rept. 15 Sep 1995-14 Sep 1996
MIAMI UNIV FL SCHOOL OF MEDICINE
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The following describes results of a two year descriptive study, with a nested case-control design, aimed at determining relationships between risk factors and genetics in breast cancer etiology among pre-menopausal African American women. One hundred breast cancer cases cases n 100 and their primary female relatives PFRs n 154 were administered several questionnaires psychosocial, reproductive, genetic and lifestyles related to disease risk. Cases were matched by ethnicity and age within 10 years to one cancer-free woman participating in a screening mammography program n 100. Results showed less than 35 of Cases Siblings believed there is a lot they can do from getting cancer compared to 9 of Mothers and 21 of Offspring. More than 50 of Cases Siblings are pleased with the emotional support provided by family and friends, respectively. Cases reported starting their menstrual cycle at age 13 and Controls, age 12. DNA samples have been extracted from the blood of all cases and PFRs. Eight participants 19 had a positive reported family history for breastovarian cancer with at least one more affected relative. Over 30 of Cases Siblings were overweight as opposed to 2 of Mothers and 19 of Offspring.
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