The Molecular Epidemiology of Breast Cancer: Risk from Environmental Exposures and Genetic Susceptibility.
Annual rept. 1 Sep 95-31 Aug 96,
STATE UNIV OF NEW YORK AT BUFFALO AMHERST
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This work is a continuation of the effort to determine environmental and genetic determinants of breast cancer. Since the last report data on serum organochlorine levels, e.g. serum DDE, HCB, total PCBs, and mirex, became available. These data were explored by first conducting a thorough descriptive analysis. Results from this cross-sectional research suggested that increased fruit and vegetable intake may be associated with higher levels of serum DDE, HCB, and total PCBs. No associations with fish intake were observed for any of the compounds under investigation. Weak associations were found for intake of individual meats and dairy products and serum levels of DDE, HCB, and total PCBs. Caffeine intake appeared to be inversely related to DDE, HCB, and total PCBs. We observed no strong inverse associations with any of these compounds and duration of lactation. Future analytic efforts will focus on the association between these organochlorine compounds and breast cancer risk.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research
- Food, Food Service and Nutrition