Accession Number:
ADB218568
Title:
Oral Vaccination Against Anthrax Using a Transgenic Plant Expressing Protective Antigen.
Descriptive Note:
Final rept. 15 Aug 1995-14 Aug 1996
Corporate Author:
CROPTECH DEVELOPMENT CORP BLACKSBURG VA
Personal Author(s):
Report Date:
1996-09-01
Pagination or Media Count:
34.0
Abstract:
The goal of this proposal is to develop transgenic plants for the production of oral food-based delivery of new recombinant vaccines against the plague and anthrax. The major goal of the Phase 1 contract was to generate transgenic plant material expressing three different antigens the Bacillus anthracis protective antigen PA, the Yersinia pestis V antigen modified to contain a His6 epitope to facilitate affinity purification His-Tag V, and the Y pestis F1 antigen, with potential for anthrax and bubonic plague vaccines, respectively. We will briefly introduce the disease and the rationale for selection of targeted antigens.
Descriptors:
Subject Categories:
- Biochemistry
- Medicine and Medical Research
- Pharmacology