Accession Number:

ADB218568

Title:

Oral Vaccination Against Anthrax Using a Transgenic Plant Expressing Protective Antigen.

Descriptive Note:

Final rept. 15 Aug 1995-14 Aug 1996

Corporate Author:

CROPTECH DEVELOPMENT CORP BLACKSBURG VA

Personal Author(s):

Report Date:

1996-09-01

Pagination or Media Count:

34.0

Abstract:

The goal of this proposal is to develop transgenic plants for the production of oral food-based delivery of new recombinant vaccines against the plague and anthrax. The major goal of the Phase 1 contract was to generate transgenic plant material expressing three different antigens the Bacillus anthracis protective antigen PA, the Yersinia pestis V antigen modified to contain a His6 epitope to facilitate affinity purification His-Tag V, and the Y pestis F1 antigen, with potential for anthrax and bubonic plague vaccines, respectively. We will briefly introduce the disease and the rationale for selection of targeted antigens.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE