Accession Number:

ADB215487

Title:

Development of Modified Biodegradable Polymers for Osmotically Driven Biodegradable Implant Therapeutic System (OBITS) for (PANDA)

Descriptive Note:

Final rept. 15 Mar-14 Sep 1996

Corporate Author:

DPD INC LANSING MI

Personal Author(s):

Report Date:

1996-09-01

Pagination or Media Count:

30.0

Abstract:

The ultimate goal of the proposed project is the development of a novel drug delivery system which is capable of providing long-lasting pain relief utilizing local anesthetics while reducing the debilitating side effects associated with current pain management therapies. In Phase I research the technical and commercial feasibility of developing a controlled release delivery system based on the microporous membranes was demonstrated. Microporous membranes were fabricated from biodegradable polymers using various hydrophilic water soluble agents. It was demonstrated by SEM that upon contact with water the hydrophilic agents leave the polymer forming a microporous membrane. The kinetics of pore formation studies indicated that pores were formed very rapidly in the membranes. The transport studies indicated that pores were formed in the membranes and the transport of the drugs across the membranes is dominantly through the pores formed within the membranes thus eliminating drugpolymer interactions. The long term mechanical testing indicate that the mechanical integrity of the membrane does not deteriorate after prolonged exposure to buffer used to mimic biological system. The desired technical performance of the cast membranes make the technical feasibility of the proposed drug delivery system based on the microporous membranes developed in Phase I of this research extremely promising.

Subject Categories:

  • Biochemistry
  • Polymer Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE