Accession Number:

ADB215195

Title:

Micronutrient/Antioxidant Supplementation and Immune Function in Women: Effects of Physiological Stress

Descriptive Note:

Final rept. 12 Dec 94-30 Apr 96

Corporate Author:

UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD

Personal Author(s):

Report Date:

1996-04-01

Pagination or Media Count:

34.0

Abstract:

Immune responses to exercise after acute supplementation with zinc 25 mg Zn and 1.5 mg copper and vitamin E 400 IU E were evaluated in 10 eumenorrheic women. Subjects age 32 1 years were studied on three occasions once per menstrual cycle, between days 5 and 8, after supplementation with Zn, E and a placebo P. They ran at 65 to 70 of their maximal aerobic capacity to exhaustion 94, 98, and 97 minutes for Zn, E P, respectively. Blood levels of ACIFI, cortisol, prolactin, growth hormone, vitamin E, IL-6, and selected lymphocyte subset markers CD3, CD4, CD8, CD19 and CD56 were measured before PRE and immediately POST, one hour REC and the day after the run. Metabolic, hormonal and immune responses were similar for Zn, E and P with one exception percentage of CD4 cells was significantly lower p 0.05 with Zn. Under all treatments, exercise significantly p0.05 increased plasma ACTH, cortisol, prolactin, growth hormone and IL-6 concentrations. Whereas CD8 and CD56 cell percentages increased p0.05, CD4CD8 ratio, CD3, CD4, and CDl9 cell percentages decreased p 0.05 at POST. These responses were temporary as most REC values were similar to PRE.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE