Accession Number:

ADB213334

Title:

Sickle Cell Trait and Frostbite

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s):

Report Date:

1952-04-14

Pagination or Media Count:

14.0

Abstract:

To determine the importance of the sickle cell trait as a predisposing factor in the pathogenesis of cold injury. The sickle cell trait occurred with essentially equal frequency in a group of 346 control Negroes 10.4 and a frostbite group of 66 cases 13.6. The sickle trait occurred with essentially equal frequency in a group of control cases tested before exposure to cold 10.9 and a similar group tested after prolonged exposure to cold 9.6. There was no significant difference between the. sickling and non-sickling distribution in the four main blood groups when the frostbite and control groups were compared. The four main blood groups appeared with equal frequency in the frostbite and control groups. No significant correlation was found between the occurrence of the sickle cell trait and the presence of cold agglutinins in the frostbite, pre-exposure control and post-exposure control groups. The presence of the sickle cell trait in Negroes does not appear to be a significant factor in the causation of frostbite in this group.

Subject Categories:

  • Medicine and Medical Research
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE