Accession Number:

ADB210896

Title:

Drug Evaluation in the Plasmodium Falciparum-Aotus Model

Descriptive Note:

Annual rept. 1 Mar 95-28 Feb 96

Corporate Author:

PROMED TRADING S A MIAMI FL

Report Date:

1996-03-01

Pagination or Media Count:

27.0

Abstract:

Its metabolite desbutylhalofantrine was less effective than halofantrine in curing Vietnam Oak Knoll P, falciparum infections, MSP-1, a DNA erythrocytic vaccine did not prevent virulent infections after Oak Knoll challenge. Sterile immunity in Aotus has been achieved by repeated Oak Knoll challenges. A fourth immunization with a DNA pre-erythrocytic vaccine has produced high antibody levels. To date, sporozoites of the 3D7 clone of P, falciparum have not produced patent infections. Vaccination with Interleukin-12 did not yield gamma interferon in Aotus, A fourth i.d. vaccination with DNA Py CSP vaccine generated highly significant antibody titers.

Subject Categories:

  • Pharmacology
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE