Drug Evaluation in the Plasmodium Falciparum-Aotus Model
Annual rept. 1 Mar 95-28 Feb 96
PROMED TRADING S A MIAMI FL
Pagination or Media Count:
Its metabolite desbutylhalofantrine was less effective than halofantrine in curing Vietnam Oak Knoll P, falciparum infections, MSP-1, a DNA erythrocytic vaccine did not prevent virulent infections after Oak Knoll challenge. Sterile immunity in Aotus has been achieved by repeated Oak Knoll challenges. A fourth immunization with a DNA pre-erythrocytic vaccine has produced high antibody levels. To date, sporozoites of the 3D7 clone of P, falciparum have not produced patent infections. Vaccination with Interleukin-12 did not yield gamma interferon in Aotus, A fourth i.d. vaccination with DNA Py CSP vaccine generated highly significant antibody titers.