Accession Number:

ADB205250

Title:

Production of Polyclonal Antibodies in Rabbits

Descriptive Note:

Final rept. 1 Mar 1993-31 Aug 1995

Corporate Author:

BIOTEK INC WOBURN MA

Personal Author(s):

Report Date:

1995-10-01

Pagination or Media Count:

103.0

Abstract:

The project was directed to the Medical Chemical Defense Research Program. Under the broad mission of providing medical countermeasures to chemical warfare agents, the work was relevant to develop the use of exogenous cholinesterase enzymes as a pretreatment to protect against organophosphorous chemical agents. The threat of deadly exposure to chemical agents is still significant for American military personnel and the American public. The recent use of sarin by Japanese extremists in subway sta- tions in Japan is witness to that. Amongst the most lethal chemical agents are organophosphorous OP compounds such as soman, sarin, and tabun. Poisoning from these agents can lead to rapid and severe dysfunction and even death from respiratory failure within five minutes Gilman, et al., 1990.

Subject Categories:

  • Medicine and Medical Research
  • Biochemistry
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE