Non-Invasive Deep Tissue Oxygenation Sensor.
Final rept. 15 Mar-14 Sep 95 on phase 1,
VIXEL INC BROOMFIELD CO
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This Small Business Innovation Research Phase I project proved the feasibility of a compact and low cost instrument to measure tissue oxygenation based on near-infrared NIR spectroscopy. NIR light in the .7-1.1 um range penetrates human tissue to a depth of several centimeters, and is attenuated during transmission by oxyhemoglobin, deoxyhemoglobin, melanin, water and cytochrome aa3, each with its own characteristic absorption spectrum. NIR absorption spectroscopy offers a number of advantages in comparison with other oxygen measurement modalities it is non-invasive, uses non-ionizing radiation, offers high spatial and temporal resolution, and supplies new types of metabolic and functional information for low cost, rapid, bedside diagnostic procedures. The Phase I project determined the most practical means to implement a hand-held NIR spectroscopic oxygenation monitor, specified the components needed, defined the measurement method and assessed the practicality of the instrument for phase II development
- Atomic and Molecular Physics and Spectroscopy
- Medicine and Medical Research
- Organic Chemistry