Accession Number:

ADB198405

Title:

Drug Evaluation in the Plasmodium falciparum - Aotus Model

Descriptive Note:

Annual rept. 1 Mar 94-28 Feb 95

Corporate Author:

PROMED TRADING S A MIAMI FL

Personal Author(s):

Report Date:

1995-03-24

Pagination or Media Count:

49.0

Abstract:

A pyrroloquinazoline was toxic to Aotus. Blood induced infections of the AMRU-1 P. vivax strain were not cured with primaquine plus chloroquine. A primaquine analog plus chloroquine cured infections with CQR vivax parasites, indicating in-Vivo reversal. The FVO P. falciparum strain was reestablished in Panamanian Aotus to induce immunity acquire by repeated trophozoite challenge. Patent infections were induced in Aotus by Santa Lucia P. falciparum strain trophozoites and sporozoites, a potential model to evaluate DNA vaccines. A DNA plasma vaccine encoded for the p. yoelli CSP gene elicited significant antibodies by intradermal needle injection.

Subject Categories:

  • Pharmacology
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE