Accession Number:

ADB173254

Title:

Drug Evaluation in the Plasmodium Falciparum - Aotus Model

Descriptive Note:

Annual rept. 1 Mar 92-28 Feb 93

Corporate Author:

PROMED TRADING S A MIAMI FL

Personal Author(s):

Report Date:

1993-03-23

Pagination or Media Count:

32.0

Abstract:

The Panamanian Aotus - Plasmodium falciparum model was used to evaluate potential antimalarial rugs additionally, ah Aotus-adapted P. vivax strain was tested for its susceptibility to chloroquine. A water-soluble form of WR 268668, a bisoquinoline was ineffective against Vietnam SmithRE infections. Two trioxanes WR 279137 and WR 279138 and a tetroxane WR 148999 cured infections at doses equivalent to arteether WR 255131 used as a positive drug control for these experiments. Infections of the Singleton strain of P. vivax were cured by doses of chloroquine that routinely cure such infections, showing that these parasites did not demonstrate a resistance to chloroquine. In a third trial to reverse chloroquine resistance in vivo SmithRE infections, a loading dose of chloroquine was followed eight hours later with a dose of promethazine. Primary treatments only suppressed parasitemias while re-treatments at 2x the respective primary dose cleared parasitemias. Post treatment blood film examination to ascertain infection cure is in progress. RA J, Malaria, P. Falciparum, Aotus monkey, Antimalarial, Drug evaluation, Lab animals.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE