Accession Number:

ADB166046

Title:

Research in Drug Development against Viral Diseases of Military Importance (Large-Scale Antiviral Drug Screening). Volume 1

Descriptive Note:

Technical Report,01 Feb 1991,03 Mar 1991

Corporate Author:

SOUTHERN RESEARCH INST BIRMINGHAM AL BIRMINGHAM United States

Report Date:

1991-12-31

Pagination or Media Count:

368.0

Abstract:

The purpose of this program was to evaluate the efficacy of candidate antiviral compounds against a spectrum of viruses of military importance. This program involved a prescreen vitro, b primary testing of synthetic compounds and active natural products in vitro against an expanded spectrum of viruses of military importance, c confirmatory testing of all active lead compounds from the prescreen and primary screen, d secondary in vitro and in vivo studies of selected active compounds with best broad spectrum antiviral activity. The target viruses for in vitro testing were Vaccinia Virus VV, Yellow Fever Virus YF, Japanese Encephalitis Virus JE, Venezuelan Equine Encephalomyelitis Virus VE, Punta Toro Virus PT, Sandfly Fever Virus SF and Human Immunodeficiency Virus HIV. The secondary in vitro and in vivo testing was carried out with three major classes of viruses aFiloviruses, b Arenaviruses and c Bunyaviruses. Approximately 5500 2762 prescreen compounds and 2713 primary screen compounds were received for in vitro evaluation and over 34,000 assays were performed on this contract. Compounds were identified in nearly all virus systems that have confirmed antiviral activity equal or exceeding that of the various positive control compounds Ribavirin, Selenazofurin, Ara-A, ddC and AZT. Many of these compounds represent potent and selective new antiviral agents. Antiviral Drugs, In Vitro, HIV Exotic RNA Viruses, In Vivo, DNA Viruses, RA 1.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE