Chemotherapy Studies Using Compounds Tested against Viruses of Military Importance
Technical Report,08 Jan 1991,31 Dec 1991
UTAH STATE UNIV LOGAN LOGAN
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Military Relevance The viruses of military significance targeted by this research are sandfly fever virus and Rift Valley fever virus, both endemic to the Middle Eastern area and capable of severely hampering military operations if an outbreak occurs in susceptible populations and Lassa fever, Junin, and Machupo viruses, all endemic to Africa or South America. The Punta Toro virus is a closely related viruses which is safer to use in the laboratory and which, as target for antiviral agents, has been shown to be highly predictable of efficacy against sandfly and Rift Valley fever viruses. The Pichinde virus is a closely related virus to the Lassa fever, Junin and Machupo viruses and is highly predictable of efficacy against these viruses. In Vivo Assessment of Lethal Toxicity Approximate LD50 values were obtained in mice for 19 AVS compounds and in hamsters for 4 AVS compounds. Effect of AVS Compounds on Hepatotropic Infections In Mice Induced by the Adames Strain of Punta Toro Virus A total of 64 experiments were run in evaluating 29 AVS compounds against the hepatotropic PTV infection. Ribavirin AVS01 and six chemical derivatives were considered markedly effective and acting specifically against the virus infection. A total of 23 immunomodulating substances also had strong anti-PTV effects. Punta Toro virus, Bunyavirus, Phlebovirus, Pichinde virus, Animal infection, RAI, Immunomodulators, Antiviral.