Drug Development Against Viral Diseases.
Annual rept. 1 Feb 90-31 Jan 91,
YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE
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Quinolamine Riker Laboratories, AVS 1018 was eminently promising in the yellow fever virus primate model. Treatment before and after virus infection protected 5 virus inoculated monkeys from disease for 25 days. Two of 3 untreated cynomolgous monkeys infected with the Asibi strain of yellow fever virus died within 5 days of infection. Viremia in treated-monkeys was delayed and markedly reduced. Measurable alphabeta interferon was present in serum of drug-treated animals weeks after initiating and maintaining drug therapy. Surviving monkeys developed dermal lesions when inoculated with wild-type vaccinia virus. Anti-viral drugs Vaccinia virus Yellow fever virus RA 1.
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