Conduct Studies to Synthesize Antiviral Compounds.
Final rept. 20 Sep 90-19 Sep 91,
ANDRULIS RESEARCH CORP BETHESDA MD
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Ribavirin a broad spectrum antiviral compound shows promise in vitro and in vivo against many viral diseases. The specific aim of this project was to synthesize a polymeric drug conjugate of ribavirin to provide time-release doses with enhanced endocytosis. A practical and standard approach was planned to couple ribavirin with carboxy-dextran MW 46,000 by protecting 2, 3-hydroxyl groups of ribavirin and then coupling ribavirin with polymer via an ester linkage to the 5-hydroxyl group. This report describes successful synthesis and characterization of 2 3-isopropylidine ribavirin and carboxy-dextran. Conjugation of ribavirin to polymer may provide enhanced solubility and sustained release of drug. Further, a recommendation is also made in this report to achieve successful synthesis of conjugates.