Drug Development against Viral Diseases
Technical Report,01 Feb 1989,31 Jan 1990
YALE UNIV NEW HAVEN CT NEW HAVEN
Pagination or Media Count:
Ninety-three drugs were tested against LCMV in the adult mouse model. Fourteen drugs gave VR scores greater than 1.2 which places these drugs in the top 90th percentile of all drugs tested in the LCMV model. The identity of the ribavirin resistant virus has been established by mouse neutralization test using acetone-ether extracted CCHF virus mouse polyclonal antibody. There were no breakthrough mice in the neutralization test. Ribavirin-resistant virus was re-isolated from liver tissue of infected mice.