Synthesis of Antidotes for Organophosphorus Acetylcholinesterase Inhibitors
Annual rept. 1 Jan-30 Jun 91, Final rept. 1 Jan 1989-30 Jun 1991
VIRGINIA UNIV CHARLOTTESVILLE
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This report describes the preparation of 73 new compounds prepared for evaluation as antidotes andor prophylactic agents against the toxicity of organophosphorus acetylcholinesterase inhibitors. The compounds prepared included heteroaromatic bis-cations 11 examples heteroaromatic mono-cations 13 examples phenoxymethyl heteroaromatic carbamates 12 examples imidazopyridinium salts 32 examples and miscellaneous compounds 5 examples. The preparative methods are described. For any compound in vitro activity as inhibitors of acetycholinesterase is given. Some compounds have also been evaluated for in vivo prophylactic and antidotal activity.
- Chemical, Biological and Radiological Warfare