Accession Number:

ADB159050

Title:

Synthesis of Antidotes for Organophosphorus Acetylcholinesterase Inhibitors

Descriptive Note:

Annual rept. 1 Jan-30 Jun 91, Final rept. 1 Jan 1989-30 Jun 1991

Corporate Author:

VIRGINIA UNIV CHARLOTTESVILLE

Personal Author(s):

Report Date:

1991-08-30

Pagination or Media Count:

65.0

Abstract:

This report describes the preparation of 73 new compounds prepared for evaluation as antidotes andor prophylactic agents against the toxicity of organophosphorus acetylcholinesterase inhibitors. The compounds prepared included heteroaromatic bis-cations 11 examples heteroaromatic mono-cations 13 examples phenoxymethyl heteroaromatic carbamates 12 examples imidazopyridinium salts 32 examples and miscellaneous compounds 5 examples. The preparative methods are described. For any compound in vitro activity as inhibitors of acetycholinesterase is given. Some compounds have also been evaluated for in vivo prophylactic and antidotal activity.

Subject Categories:

  • Biochemistry
  • Toxicology
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE