Systematic Mustard Gas Scavengers
Midterm progress rept. 5 Mar 1990-4 Mar 1991
SRI INTERNATIONAL MENLO PARK CA
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The synthesis methodology for preparing four types of novel nucleophilic scavengers for experimental treatment of HD intoxication is described. The four types include 3-alkoxyquinuclidines, 4-dialkyl aminopyridines, N-alkylpyridine-4-thiones, and imidazoline-2-thiones. A total of 4 compounds representing three of the classes were prepared, characterized, and submitted to WRAIR for biological evaluation. In addition, a convenient kinetic screen to rank target compounds in order of relative reactivity was established.
- Chemical, Biological and Radiological Warfare