Determination of the In vitro and In vivo Activity of Compounds Tested against Punta Toro Virus
Technical Report,01 Dec 1989,30 Dec 1990
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Approximate LD50 values were obtained in 3-4 week-old C57BL6 mice or 4-5 week-old Swiss Webster mice for 37 AVS compounds. Effect of AVS Compounds on Hepatotropic Infections in Mice Induced by the Adames Strain of Punta Toro Virus A total of 64 anti-PTV experiments were run with 25 AVS compounds using the Adames strain of PTV. Promising compounds included AVS65, 79, 111, 272 347, 1761, 1968, 2276, 2285, 2812, and 5311. Effect of AVS Compounds on Intracerebral Infections in Mice Induced by the Balliet Strain of Punta Toro Virus A total of 16 AVS compounds were evaluated against the CNS infection induced by the Balliet strain of PTV. Compounds AVS6080 and 6082 were considered moderately effective. Comparison of the Effects of AVS01, AVS02, and AVS06 on Daily Disease Parameters in Punta Toro Virus-Infected Mice A single p.o. treatment given 24 hr post-virus inoculation with LD5016 dosages of AVS01, 02, or 206 prevented the PTV-associated death of the mice and significantly lowered the already developing viral titers in the blood and all tissues. In this experiment, AVS01 was least effective in keeping the virus below detectable limits. AVS206 was consistently most effective.