Task 89-06: Determination of the Bioequivalence of HI-6 and Atropine When Delivered by Wet/Dry Autoinjector or Syringe in Sheep: A Pharmacokinetic and Efficacy Evaluation
Final rept. 1 Oct 1989-15 Apr 1991
BATTELLE COLUMBUS DIV OH
Pagination or Media Count:
A study was instituted in sheep to compare efficacy against Soman and the pharmacokinetics of atropine and HI-6 by wetdry autoinjector and by syringe. The efficacy in sheep against Soman of AtropineHI-6 delivered by wet dry autoinjector was also compared to the efficacy of atropinepralidoxime chloride when syringe. The aging rate of GD was also determined in sheep erytrocytes. There were no statistical differences in the LD50s of sheep treated with atropineHI-6 using syringes of wetdry autoinjectors. A PR was determined for atropineHI-6 treatment. Based on analyses of HI-6 and atropine pharmacokinetic parameters there were no statistically significant differences in the two injection techniques. The aging rate of sheep RBCs is highly dependent upon the GD-AChE incubation temperature.
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