Synthesis of Antidotes for Organophosphorus Acetylcholinesterase Inhibitors.
Annual rept. 1 Jan-31 Dec 90,
VIRGINIA UNIV CHARLOTTESVILLE
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This report describes the preparation of heteroaromatic carbamates for evaluation of prophylactic and antidotal activity against organophosphorus OP acetylcholinesterase inhibitors. Synthetic procedures for 27 new compounds are included. Both in vitro acetycholinesterase activity and in vivo prophylactic and antidotal activity against OP toxicity is reported for several of the compounds prepared earlier in the project. Tentative structure activity relationships are considered.