Inhibition of Malarial DNA Polymerase Alpha
Midterm rept. 15 Apr 1989-14 Oct 1990
VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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Plant extracts have been surveyed in an effort to locate natural principles capable of mediating potent, specific inhibition of malaria DNA polymerase alpha. Several extracts containing putative polymerase inhibitors have been shown to inhibit cultured Plasmodium falciparum. Also underway are efforts to clone and express the gene for P. falciparum. Also underway are efforts to clone and express the gene for P. falciparum DNA polymerase alpha, which would provide access to unlimited amounts of the enzyme for screening and isolation of polymerase alpha inhibitors.
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