Accession Number:

ADB151470

Title:

Inhibition of Malarial DNA Polymerase Alpha

Descriptive Note:

Midterm rept. 15 Apr 1989-14 Oct 1990

Corporate Author:

VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

1990-11-14

Pagination or Media Count:

26.0

Abstract:

Plant extracts have been surveyed in an effort to locate natural principles capable of mediating potent, specific inhibition of malaria DNA polymerase alpha. Several extracts containing putative polymerase inhibitors have been shown to inhibit cultured Plasmodium falciparum. Also underway are efforts to clone and express the gene for P. falciparum. Also underway are efforts to clone and express the gene for P. falciparum DNA polymerase alpha, which would provide access to unlimited amounts of the enzyme for screening and isolation of polymerase alpha inhibitors.

Subject Categories:

  • Pharmacology
  • Sociology and Law

Distribution Statement:

APPROVED FOR PUBLIC RELEASE