In Vitro and In Vivo Measurement of Percutaneous Penetration of Low Molecular Weight Toxins of Military Interest
Annual rept. 22 Dec 1989-21 Sep 1990
AUBURN UNIV AL SCHOOL OF PHARMACY
Pagination or Media Count:
The purpose of this contract is to i use an in vitro system to assess the ability of low molecular weight toxins to penetrate through human and guinea pig skin ii validate the results obtained in the in vitro system by conducting comparative studies of in vitro and in vivo cutaneous penetration in guinea pigs, iii assess the effects of specific solvent vehicles on the cutaneous penetration of the low molecular weight toxins, and iv modify the in vitro experimental system for skin penetration for use in studies of in vitro penetration across mucosal membranes. Toxins to be studied include the brevetoxins, microcystins, lyngbyatoxin A and debromoaplysiatoxin.