Bridged Bicyclic Systems as Acetylcholinesterase Reactivators and Pretreatment Drugs.
Annual rept. 15 Jul 88-14 Jul 89,
ILLINOIS UNIV AT CHICAGO CIRCLE
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During the past year a large number substituted carbamates, thiocarbamates of various bridged aza bicyclic oximes and their methiodides and meth chlorides have been synthesized. Among these are i O-N-Substituted carbamoyl-3-tropinone oxime methiodides and methchlorides, ii 0-N-Substituted carbamoyl-6-cyano trop-3-ene-2-one oxime methiodides, iii O-N-2,3,4,6-Tetra-0-acetyl-b-D-glucopyranosyl thiocarbamoyl-3-tropinone oxime and its methiodide. Synthesis of 1,6-bis-N,N-dimethyl-3-oximino-0-carbamoyl tropanonium-N-y1 hexane diiodide and 2,5- bis-NN-dimethyl-3-oximino-0-carbamoyl tropanonium-N-yl-toluene diiodide have been achieved. From phencyclidine a series 4-phenyl-4-0-N-substituted carbamoyl-4-piperidone oxime-1-yl-1-methyl piperidone methiodides have been synthesized. Syntheses of 0-N-substituted carbamoyl-3-exo-dimethyl aminomethyl2-norbornone oximes and their methiodides have been accomplished.
- Organic Chemistry