Accession Number:

ADB148205

Title:

Research in Drug Development against Viral Diseases of Military Importance (Biological Testing)

Descriptive Note:

Technical Report,15 Nov 1987,04 Nov 1988

Corporate Author:

SOUTHERN RESEARCH INST BIRMINGHAM AL BIRMINGHAM United States

Personal Author(s):

Report Date:

1988-12-15

Pagination or Media Count:

409.0

Abstract:

The purpose of this program is to evaluate the efficacy of candidate antiviral compounds against a spectrum of viruses of military importance. This program involves a primary testing of chemical compounds and natural products for antiviral efficacy in vitro using CPE-inhibition and plaque-reduction assays, b primary testing of compounds for antiviral efficacy in vivo in animal model systems, and c secondary evaluation of the active candidate antiviral compounds. The target viruses for in vitro testing are Vaccinia Virus VV, Adenovirus AD2, Vesicular Stomatitis Virus VSV, Punta Toro Virus PT, Sandfly Fever Virus SF, Yellow Fever Virus YF, Venezuelan Equine Encephalomyelitis Virus VEE, Japanese Encephalitis Virus JE, Pichinde Virus PIC, and Hantaan Virus HTN. The current in vivo systems are Pichinde Virus infection of hamsters, Venezuelan Equine Encephalomyelitis Virus, Japanese Encephalitis Virus and Vaccinia Virus infections of mice. Over 2600 compounds have been received for in vitro evaluation and over 14,000 assays have been performed on this contract to date. Compounds have been identified in nearly all virus systems that have confirmed antiviral activity exceeding that of the various positive control compounds Ribavirin, Selenazole, and Ara-A. Many of these compounds represent potent and selective new antiviral agents.

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Distribution Statement:

APPROVED FOR PUBLIC RELEASE


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