Accession Number:

ADB148116

Title:

Synthesis of Phosphates and Phosphonates of 1',2'-Seco-Nucleosides and Other Antivirals

Descriptive Note:

Technical Report,12 Jun 1989,31 Jan 1990

Corporate Author:

RHODE ISLAND UNIV KINGSTON KINGSTON

Personal Author(s):

Report Date:

1990-03-02

Pagination or Media Count:

14.0

Abstract:

Synthetic methodologies for the preparation of nucleoside phosphates and phosphonates have been developed. Phosphates as well as cyclic phosphates have been synthesized. A unique reaction was discovered that allows the preparation of phosphonate chirons. The latter have been successfully converted to 1,2-seco-nucleoside phosphonates and homophosphonates.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE