Accession Number:
ADB148116
Title:
Synthesis of Phosphates and Phosphonates of 1',2'-Seco-Nucleosides and Other Antivirals
Descriptive Note:
Technical Report,12 Jun 1989,31 Jan 1990
Corporate Author:
RHODE ISLAND UNIV KINGSTON KINGSTON
Personal Author(s):
Report Date:
1990-03-02
Pagination or Media Count:
14.0
Abstract:
Synthetic methodologies for the preparation of nucleoside phosphates and phosphonates have been developed. Phosphates as well as cyclic phosphates have been synthesized. A unique reaction was discovered that allows the preparation of phosphonate chirons. The latter have been successfully converted to 1,2-seco-nucleoside phosphonates and homophosphonates.