Development of Methods for Carrier-Mediated Targeted Delivery of Antiviral Compounds Using Monoclonal Antibodies
Technical Report,01 Apr 1988,31 Mar 1989
SRI INTERNATIONAL MENLO PARK CA MENLO PARK United States
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SRI International and Utah State University are developing methodology to assess the effectiveness of antiviral drug-monoclonal antibody conjugate therapy for the treatment of viral infections. Specifically, monoclonal antibodies to Pinchinde virus surface antigens were prepared and conjugated to the antiviral drug ribavirin, and the resulting conjugates will be screened for antiviral activity both in vitro and in animal model systems.