Chemical Blistering: Cellular and Macromolecular Components.
Annual rept. 1 Jan-31 Dec 87,
MICHIGAN UNIV ANN ARBOR
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The overall purpose of this investigation is to elucidate the molecular mechanisms by which bisbeta-chloroethyl sulfide BCES exerts its vesicant action when applied topically to human skin by establishing morphological, cytochemical andor biochemical indicators of mustard toxicity in cultures of keratinocytes and examining and evaluating the relevance of these parameters to vesication. During the second year of this project, the investigation has attempted to a confirm that DNA is the macromolecular system which is most sensitive to damage in cultures exposed to BCES, b identify the lowest level of exposure at which the lesion in DNA can be observed and the level of exposure at which the lesion in DNA can be observed and the level of exposure at which the lesion cannot be repaired. Keywords Mustard, Keratinocyte, Tissue culture, ALkylation, Toxicity, Chemical blistering, Mitochondria, Metabolism, DNA Repair, Epidermal proliferation, Epidermal differentiation. JES
- Chemical, Biological and Radiological Warfare