Accession Number:

ADB145250

Title:

New Drugs for Pretreatment of Organophosphonate Intoxication

Descriptive Note:

Final rept. 15 Nov 1987-14 Nov 1989

Corporate Author:

SRI INTERNATIONAL MENLO PARK CA

Report Date:

1990-02-20

Pagination or Media Count:

105.0

Abstract:

Our work has focused on the synthesis of compounds having the general structures shown below. Eighty-four compounds were synthesized and submitted to the U.S. Army Medical Research and Development Command MRDC. In addition, two previously submitted 12-phenylmethylcycloalkylamines were resynthesized at the request of the Contracting Officers Representative COR for further in vivo testing. Forty-five 1-1-arylcycloalkylmethylamines were submitted. Structural variables examined included the phenyl substituent unsubstituted, 3- OCH3, 3-OH, 3,4-OCH32, 4-CH3, and 4-NO2, the cycloalkyl ring cyclohexyl, cyclopentyl, cyclopropyl, and replacement of the cycloalkyl ring with two ethyl groups, the amine pyrrolidine, piperdine, morpholine, diethylamine, and dimethylamine, the aryl group substituted and unsubstituted phenyl, 2-thienyl, and 1-naphthyl, and protic verses quaternary methyl salts. Keywords Pretreatment, Antidote, Organophosphonate, Synthesis, Acetylcholinesterase, Anticholinesterase.

Subject Categories:

  • Toxicology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE