Synthesis of Improved Antileishmanial and Antitrypanosomal Drugs, Treatment and Prophylaxis
Final rept. 1 Sep 1984-30 Jun 1988
ASH STEVENS INC DETROIT MI
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The work reported herein was directed at the preparation of improved antileishmanial and antitrypanosomal drugs. During the contact period forty six months, 46 candidate drugs were submitted for biological testing. This program was divided into five phases of work 1 Analogs of WR 6026 eleven 2 Potential metabolites and analogs of a known metabolite WR 6026 seven 3 Bis-amidoxime and bis-amidines four 4 Dimethylaminomethyl ethylenes similar to Burroughs Welcome 353 C seventeen and 5 Amidoximinio ethylenes seven. Twenty eight of the target compounds prepared were directed against Trypanosoma cruzi infections, while the remaining eighteen compounds were targeted against Leishmaniasis. Keywords Antileishmanials, Metabolites of 8-6- diethylaminohexylamino-6-methoxy-4-methylquinoline, WR 6026, RA 1, Organic compounds, Drugs.
- Organic Chemistry