Unique Purine Nucleosides with Broad-Spectrum RNA Antiviral Potential
Technical Report,12 Jun 1989,31 Jan 1990
IOWA UNIV IOWA CITY IOWA CITY United States
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This project is concerned with the biochemically-based rational design, synthesis, purification, complete spectral characterization, and antiviral evaluation of some unique adenine and hypoxanthine deoxynucleosides. A total of seven compounds were produced through complex multi-step syntheses and submitted for antiviral evaluation. The work at present is right on schedule and in complete accordance with the contract agreement. Based on previous results from our laboratory, information on the exotic ribonucleic acid viruses and their key enzymes, rational design, and the current status of antiviral research in this and related areas, this project has a very high probability of producing antivirally active compounds of relevance and importance to the drug development program of the USAMRDC. Deoxynucleosides, Synthesis, RNA Antiviral molecules, Drug synthesis, Antiviral drugs, Drug development, RNA viruses, Encephalitis, Army, Medical research.