Enhancement of Antiviral Agents through the Use of Controlled-Release Technology
Annual rept. 1 Feb 1987-31 Jan 1988
SOUTHERN RESEARCH INST BIRMINGHAM AL
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The major objectives of this research program are to develop a programmed-release delivery system microcapsule system designed to enhance the immunogenic potential of an inactivated killed Japanese Encephalitis JE virus vaccine, allowing for immunization against this viral agent and, to develop controlled-release microcapsule delivery systems that will enhance the effects of the following immune modulators and antiviral agents muramyl tripeptide MTP, interferon IFN, and polyriboinosinic acid-ribocytidylic acid POLYI C. More specifically, we are involved in the development of biocompatible, biodegradable, controlled-release microcapsule formulations to release polyI C, interferon IFN, and JE vaccine at controlled rates after a single intramuscular or intravenous administration. We also plan to develop microcapsule formulations that will target the release of MTP to macrophages, causing macrophage activation and subsequent nonimmune protection against active viral infections. During this year of the research program, we performed immunization studies with a prototype JE microcapsule formulation. The results obtained to date indicate the anti-JE antibody is present in the animals 136 days after administration of the prototype microcapsule formulation.