Detoxication of Mycotoxins and Other Toxins and Compounds of Military Interest
Annual summary rept. 15 Nov 1985-14 Jan 1987
CORNELL UNIV MEDICAL COLL NEW YORK DEPT OF BIOCHEMISTRY
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This research, was initially concerned with detoxication of certain trichothecene toxins, and has recently changed its emphasis and is now directed toward the cyanoginosin toxins. Studies on the tricothecenes have been brought to a conclusion. A newly recognized naturally occurring glutathione derivative Gamma-glutamyl glutathione has been prepared and methods for large scale preparation of this compound are being developed. Other glutathione derivatives that may be useful in detoxication are also under study. Cyanoginosin toxin, supplied to us by the Army, has been identified as of the LR type. Structural features of this toxin have been investigated and its toxicity has been studied after chemical modification. Preliminary studies indicate that the dehydropeptide moiety of the cyanoginosin LR toxin is essential for toxicity. This is an interesting point because dehydropeptides undergo facile reaction with certain SH-containing molecules. The possible role of glutathione in the modification of toxicity due to cyanoginosin peptides is currently being explored. Keywords Liver, Kidney, L-2-Oxothiazolidine-4-carboxylate, Cyanoginosin, Microcystin, Glutathione monoethyl ester.